Day 1 :
Keynote Forum
IZNAK Andrey
Mental Health Research Center, Russia
Keynote: Interrelations of the CNS and immune system in pathogenesis and treatment of attack-like Schizophrenia
Time : 10:20-11:10
Biography:
IZNAK Andrey has completed his PhD in Physiology from M V Lomonosov Moscow State University and his DSc in Physiology from the same university. He is a Neurophysiologist, Professor of Physiology and Head of Laboratory of Neurophysiology at Mental Health Research Center (Moscow, Russia). He has published more than 60 papers on sensory and clinical neurophysiology in reputed journals and served as an Editorial Board Member of several reputed journals.
Abstract:
Contemporary views on the role of neuroinflammation and neuroplasticity processes in pathogenesis of schizophrenia, as well as significant medical-social problem of optimization of its treatment, determine the necessity of multidisciplinary approaches for investigation of brain mechanisms of this severe illness. The aim of the present study is to assess the interrelations of the CNS and immune system in patients with attack-like schizophrenia and to reveal the set of neurobiological parameters informative for individual prediction of therapeutic response. Correlation and regression analyses of quantitative clinical scores (by PANSS scale), resting EEG spectral parameters and some immunological parameters have been performed in patients with manic-delusional and hallucinatory-delusional conditions in the frames of attack-like schizophrenia. Neurobiological data obtained before the beginning of syndrome based treatment course (during visit 1) were matched with clinical scores of the same patients at the stage of remission establishment after treatment course (during visit 2). The multiple linear regression equations were created which contained only 3 to 4 (from 80) initial EEG parameters and one of four immunological parameters allowed to predict from 66 to 87 per cent of clinical scores variance after treatment course (during visit 2). The data obtained emphasize the role of neurophysiological inhibition deficit and of processes of neuroinflammation and neuroplasticity in pathogenesis of manic-delusional and hallucinatory-delusional conditions, and may be used practically for objective assessment of severity of patient’s initial clinical state, as well for elaboration of methods of individual prediction of syndrome based treatment efficacy in patients with attack-like schizophrenia.
Biography:
Dr. Praveen Kottath Veetil has completed his PhD from Mahatma Ghandi University in neurophysiology. He is currently the Head of Department of Physiology, at Avalon University School of Medicine. He has published various papers in reputed journals and has been serving as an educator and researcher of repute.
Abstract:
The effects of Catha edulis, as a CNS stimulant have been studied on various aspects, but how C.edulis influence spatial learning and memory is not clear. We hypothesize C.edulis, as it contain amphetamine like substances, will also influence spatial learning and memory. With this aim, a comparative study is conceded using another CNS stimulant, methylphenidate (MPD), an advanced therapeutic for treatment of attention deficit hyperactive disorder (ADHD). Spatial learning and memory was assessed using radial arm maze, by analyzing five dependent measures obtained on every trial: time to complete a trial, latency to first arm entry, number of reference memory errors, and number of working memory correct and incorrect errors. Taken together, our results showed that C.edulis and not MPD fed rats had impaired learning and memory, implicated by increased time to complete a trial. Either C.edulis or MPD increased attention in rats, as in both groups latency to first arm entry was less.rnrnMoreover, C.edulis fed rats were more effected in the working memory component and reference memory was intact, highlighting the significance of restricting the widespread use of C.edulis in humans. Multiple evidences and our findings strongly support the use of MPD as a choice of drug in treatment of ADHD with minimum deterioration on learning and memory, in spite of increasing attention and alertness. However, considering differential action of C.edulis and MPD on neurotransmitter systems of brain, more studies are requested for the effect of C.edulis on neurotransmitters in hippocampal network.rn